Direct C(sp<sup>3</sup>)–H acyloxylation of indolin-3-ones with carboxylic acids catalysed by KI
Yong‐Long Zhao, Yong-Qin Tang, Xing-Hai Fei, Fen‐Fen Yang, Zhuoxian Cao, Dongzhu Duan, Qingjie Zhao, Yuanyong Yang, Meng Zhou, Bin He
Abstract
The first KI-catalyzed direct acyloxylation of indolin-3-ones with carboxylic acids has been developed using 30% aq. H<sub>2</sub>O<sub>2</sub> as a green oxidant at room temperature. Moreover, mechanism studies indicated that a radical oxidation process may be involved for this transformation.
Topics & Concepts
ChemistryCatalysisMedicinal chemistryCarboxylic acidOrganic chemistryStereochemistryCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsSynthesis of Indole Derivatives