Fluoride exposure alters Ca <sup>2+</sup> signaling and mitochondrial function in enamel cells
Francisco J. Aulestia, Johnny Groeling, Guilherme Henrique Souza Bomfim, Veronica Costiniti, Manikandan Vinu, Ariya Chaloemtoem, Axel R. Concepcion, Yi Li, Larry E. Wagner, Youssef Idaghdour, David I. Yule, Rodrigo S. Lacruz
Abstract
refilling of the ER. Fluoride negatively affected mitochondrial respiration, elicited mitochondrial membrane depolarization, and disrupted mitochondrial morphology. Together, these data provide a potential mechanism underlying dental fluorosis.
Topics & Concepts
Enamel paintFluorideMineralization (soil science)ChemistryTooth enamelMitochondrionCell biologyDentistryBiochemistryBiologyMedicineInorganic chemistryNitrogenOrganic chemistryFluoride Effects and RemovalBone and Dental Protein StudiesDental Erosion and Treatment