Cytotoxicity of Cryptochlorogenic acid against Breast cancer cell line (MCF7) isolated from Moringa oleifera Leaves Cultivated in Iraq
Banan Kareem Bedewi, Ghaith Ali Jasim, Ibrahim Saleh Abbas, Basma Talib Al-Sudani
Abstract
oleifera L., a Moringaceae family is fast-growing tree. M. oleifera's dried leaves are Characterized with high in phenolic compounds. phenolic compounds have anti-cancer, anti-microbial, anti-inflammatory, anti-allergic and antioxidant activities. Therefore, The current study involved isolation Cryptochlorogenic acid by preparative TLC from M.oleifera leaves grown in Iraq, and study its cytotoxicity effect against a breast cancer cell line (MCF7) using the MTT cell viability assay, and comparing it to a standard anticancer drug (Tamoxifen). The isolated Cryptochlorogenic acid was cytotoxic to the MCF7 cell line, with an IC50 of 20.8M.
Topics & Concepts
CytotoxicityMoringaTraditional medicineViability assayMTT assayCell cultureBiologyChemistryIn vitroBiochemistryMedicineGeneticsMoringa oleifera research and applications