Improved intracellular delivery of exosomes by surface modification with fluorinated peptide dendrimers for promoting angiogenesis and migration of HUVECs
Shengnan Ma, Lei Song, Yueyue Bai, Shihao Wang, Jiao Wang, Haohao Zhang, Fazhan Wang, Yiyan He, Chuntao Tian, Guijun Qin
Abstract
as compared to exo@PG3 and exosomes. It is concluded that surface fluorine modification of exosomes with FPG3 is conducive to the cellular uptake and bioactivity of the exosome, which provides a novel strategy for engineered exosomes to enhance the biological effects of exosome-based drug delivery.
Topics & Concepts
DendrimerMicrovesiclesSurface modificationAngiogenesisIntracellularChemistryPeptideBiophysicsCell biologyNanotechnologyMaterials scienceBiochemistryCancer researchmicroRNABiologyGenePhysical chemistryExtracellular vesicles in diseaseRNA Interference and Gene DeliveryDendrimers and Hyperbranched Polymers