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ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer

Jiehui Deng, Aatish Thennavan, Igor Dolgalev, Ting Chen, Jie Li, Antonio Marzio, John T. Poirier, David H. Peng, Mirna Bulatović, Subhadip Mukhopadhyay, Heather Silver, Eleni Papadopoulos, Val Pyon, Cassandra Thakurdin, Han Han, Fei Li, Shuai Li, Hailin Ding, Hai Hu, Yuanwang Pan, Vajira Weeresekara, Baishan Jiang, Eric S. Wang, Ian M. Ahearn, Mark R. Philips, Thales Papagiannakopoulos, Aristotelis Tsirigos, Eli Rothenberg, Justin F. Gainor, Gordon J. Freeman, Charles M. Rudin, Nathanael S. Gray, Peter S. Hammerman, Michele Pagano, John V. Heymach, Charles M. Perou, Nabeel Bardeesy, Kwok‐Kin Wong

2021Nature Cancer141 citationsDOIOpen Access PDF

Topics & Concepts

AutophagyCancer researchAntigen presentationAntigenImmunotherapyImmune systemCancerLung cancerT cellImmunologyBiologyMedicineInternal medicineApoptosisBiochemistryRNA modifications and cancerAutophagy in Disease and TherapyCancer Immunotherapy and Biomarkers
ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer | Litcius