The role of mitofusin 2 in regulating endothelial cell senescence: Implications for vascular aging
Jiayin Li, Zheming Yang, Haixu Song, Lin Yang, Kun Na, Zhu Mei, Shuli Zhang, Jing Liu, Kai Xu, Chenghui Yan, Xiaozeng Wang
Abstract
+Ang II group showed elevated senescence markers in vascular tissues. These findings highlight MFN2's regulatory role in endothelial cell senescence, emphasizing its importance in maintaining endothelial homeostasis and preventing age-related vascular diseases.
Topics & Concepts
SenescenceCell biologyCellular senescenceEndothelial stem cellBiologyMFN2Angiotensin IICellEndothelial dysfunctionEndocrinologyGeneticsGenePhenotypeIn vitroMitochondrial DNABlood pressuremitochondrial fusionMicroRNA in disease regulationPregnancy and preeclampsia studiesCongenital heart defects research