Quantification anomalies in single pulse LA-ICP-MS analysis associated with laser fluence and beam size
Ana Jerše, Kristina Mervič, Johannes T. van Elteren, Vid Simon Šelih, Martin Šala
Abstract
), and matrices (gelatin standards and NIST SRM 612). The findings indicate that selection of the appropriate laser fluence, just above the ablation threshold, and beam size, depending on the interface of LA and ICP-MS, are critical for reliable quantification and should be properly adjusted to avoid excessive Poisson and Flicker noise, achieve maximum sensitivity, and prevent the formation of double peaks in single pulses.
Topics & Concepts
Inductively coupled plasma mass spectrometryFluenceLaserLaser ablationMass spectrometryMaterials scienceResolution (logic)AblationOpticsAnalytical Chemistry (journal)ChemistryPhysicsChromatographyMedicineComputer scienceArtificial intelligenceInternal medicineLaser-induced spectroscopy and plasmaAnalytical chemistry methods developmentMass Spectrometry Techniques and Applications