The hydrophobic tail of a pH-sensitive cationic lipid influences siRNA transfection activity and toxicity in human NK cell lines
Takashi Nakamura, Taisei Nakade, Koharu Yamada, Yusuke Sato, Hideyoshi Harashima
Topics & Concepts
Gene silencingTransfectionEndosomeCytotoxicityChemistryCellIntracellularGene deliveryCell cultureCationic liposomeCell biologyRNA interferenceViability assayLiposomeIn vitroBiochemistryBiologyGeneRNAGeneticsRNA Interference and Gene DeliveryImmune Cell Function and InteractionVirus-based gene therapy research