Thrombocytopenia and hyperinflammation are induced by extracellular histones circulating in blood
Rosaria Vincenza Giglio, Daniela Ligi, Chiara Della Franca, Bruna Lo Sasso, Julia Zulema Rivas, Luisa Agnello, Ferdinando Mannello, Marcello Ciaccio
Abstract
To the Editor, Circulating histones have been suggested as critical mediators and potential diagnostic/prognostic markers in several hyperinflammatory diseases, including Sars-CoV-2 infection and classical bacterial sepsis, because their levels increase with the worsening of classical and viral sepsis [1-3].
Topics & Concepts
ExtracellularMedicineNeutrophil extracellular trapsImmunologyPathologyChemistryInflammationBiochemistryNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancerPlatelet Disorders and Treatments