Synthesis, Biological Evaluation, and Molecular Modeling Studies of 1-Aryl-1<i>H</i>-pyrazole-Fused Curcumin Analogues as Anticancer Agents
Nam Q.H. Doan, Ngan T. K. Nguyen, Vu Ba Duong, Thu‐Ha Thi Nguyen, Long Binh Vong, Diem Ngoc Duong, Nguyet-Thu Thi Nguyen, Tuyen L. T. Nguyen, Thi Hong Tuoi, Tuyen Ngoc Truong
Abstract
) and access wider space at the colchicine-binding site (CBS) than that of colchicine or nocodazole via molecular docking studies. In conclusion, our study serves as a basis for the design of promising synthetic compounds as anticancer agents in the future.
Topics & Concepts
CurcuminPyrazoleApoptosisChemistryCancer cellCell cycleArylStereochemistryMicrotubuleIn vitroIC50CytotoxicityCell growthCancerPharmacologyBiochemistryBiologyCell biologyOrganic chemistryGeneticsAlkylSynthesis and biological activityCurcumin's Biomedical ApplicationsSynthesis and Characterization of Heterocyclic Compounds