Insights into recent advancements in human and animal rotavirus vaccines: Exploring new frontiers
Ahmed H. Ghonaim, Sherin R. Rouby, Wedad M. Nageeb, Ashraf Ahmed Elgendy, Rong Xu, Changsheng Jiang, Noha H Ghonaim, Qigai He, Wentao Li
Abstract
Rotavirus infections cause severe gastroenteritis and dehydration in young children and animals worldwide, leading to high rates of morbidity and mortality, predominantly in low- and middle-income countries. In the past decade, substantial progress has been made in the development and implementation of rotavirus vaccines, which have been essential in alleviating the global burden of this disease, not only in human being but also in livestock species like calves and piglets, where these infections can cause significant economic losses. By synthesizing the latest research and real-world evidence, this review article is designated to provide deep insights into the current state of rotavirus vaccine technology and its global implementation as well as the application of rotavirus vaccines in veterinary settings and their importance in controlling zoonotic transmission and maintaining food security. • Rotavirus infections cause severe gastroenteritis and dehydration in young children and animals worldwide. • Significant progress has been made in the development and implementation of rotavirus vaccines over the past decade. • The review aims to provide comprehensive insights into current rotavirus vaccine technology and its implementation. • The varying efficacy of existing rotavirus vaccines highlights the urgent need for the development of new vaccines.