<i>In Situ</i> Self-Assembly Nanomicelle Microneedles for Enhanced Photoimmunotherapy <i>via</i> Autophagy Regulation Strategy
Minglong Chen, Dan Yang, Ying Sun, Ting Liu, Wenhao Wang, Jintao Fu, Qingqing Wang, Xuequn Bai, Guilan Quan, Xin Pan, Chuanbin Wu
Abstract
remodeling the tumor immunosuppressive microenvironment. Our work provides a versatile, generalizable framework for employing self-assembled DMN-mediated autophagy inhibition integrated with photoimmunotherapy to sensitize superficial tumors and initiate optimal antitumor immunity.
Topics & Concepts
AutophagyImmunogenic cell deathCancer researchEndocytosisIn vivoImmune systemImmunotherapyChemistryApoptosisBiologyCellImmunologyBiotechnologyBiochemistryImmunotherapy and Immune ResponsesNanoplatforms for cancer theranosticsImmune cells in cancer