Extrinsic noise prevents the independent tuning of gene expression noise and protein mean abundance in bacteria
Alexandre Deloupy, Vincent Sauveplane, Jérôme Robert, Stéphane Aymerich, Matthieu Jules, Lydia Robert
Abstract
, expression noise is equally sensitive to variations in the transcription or translation rate because of the prevalence of extrinsic noise. In agreement, analysis of whole-genome transcriptomic and proteomic datasets suggests that noise optimization through transcription and translation tuning during evolution may only occur in a regime of weak transcription. Therefore, independent control of mean abundance and noise can rarely be achieved, which has strong implications for both genome evolution and biological engineering.
Topics & Concepts
Noise (video)Gene expressionGeneBacteriaBiologyProtein expressionGeneticsComputer scienceArtificial intelligenceImage (mathematics)Gene Regulatory Network AnalysisBioinformatics and Genomic NetworksCell Image Analysis Techniques