Combined fluorophore and phosphor conjugation: a new design concept for simultaneous and spatially localized dual lifetime intracellular sensing of oxygen and pH
Anastasia I. Solomatina, Pavel S. Chelushkin, Shih‐Hao Su, Chih‐I Wu, Pi‐Tai Chou, Sergey P. Tunik
Abstract
Covalent conjugation of human serum albumin with pH-sensitive fluorescein and an Ir( iii ) phosphorescent complex affords a biocompatible lifetime-based dual sensor.
Topics & Concepts
FluorophoreBiocompatibilityFluorescenceLuminescenceBiosensorChemistryConjugateIntracellularCovalent bondOxygenBiophysicsPhotochemistryMaterials scienceOptoelectronicsBiochemistryOpticsOrganic chemistryMathematical analysisBiologyPhysicsMathematicsAnalytical Chemistry and SensorsPhotoacoustic and Ultrasonic ImagingNanoplatforms for cancer theranostics