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Reducing CRISPR-Cas9 off-target effects by optically controlled chemical modifications of guide RNA

Qianqian Qi, Xingyu Liu, Wei Xiong, Kaisong Zhang, Weiliang Shen, Yuanyuan Zhang, Xinyan Xu, Cheng Zhong, Yan Zhang, Tian Tian, Xiang Zhou

2024Cell chemical biology16 citationsDOI

Topics & Concepts

CRISPRRNAComputational biologyCas9Guide RNAChemistryBiologyGeneticsGeneCRISPR and Genetic EngineeringRNA and protein synthesis mechanismsRNA Interference and Gene Delivery
Reducing CRISPR-Cas9 off-target effects by optically controlled chemical modifications of guide RNA | Litcius