Combining Enzyme and Photoredox Catalysis for the Construction of 3-Aminoalkyl Chromones
Jiayu Hu, Zongbo Xie, Juan Tang, Zhanggao Le, Zhiqiang Zhu
Abstract
Herein, we reported a practical and efficient strategy combining photoredox and enzyme catalysis for the construction of 3-aminoalkyl chromones from o-hydroxyaryl enaminones and N-arylglycine esters. A variety of 3-aminoalkyl chromones were synthesized with good yields under mild conditions in one pot. This synthetic protocol consists of sequential enzymatic hydrolysis and photoredox decarboxylation of N-arylglycine esters, oxidation of aminoalkyl radicals, Mannich reaction, and intramolecular nucleophilic cyclization, which affords a convenient pathway for the preparation of various 3-substituted chromones.
Topics & Concepts
ChemistryPhotoredox catalysisNucleophileDecarboxylationCatalysisHydrolysisIntramolecular forceRadicalOrganic chemistryCinnamatesCombinatorial chemistryPhotocatalysisSynthesis of Organic CompoundsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques