Spatial transcriptomic sequencing reveals immune microenvironment features of <i>Mycobacterium tuberculosis</i> granulomas in lung and omentum
Xiaochen Qiu, Pengfei Zhong, Liang Yu, Chaofan Li, Zhimin Yun, Guang‐Qian Si, Mengfan Li, Zhi Chen, Yingxia Tan, Pengtao Bao
Abstract
These results provide insights into the pathogenesis and development of tuberculosis, enhancing our understanding of the composition and interactions of tuberculosis granuloma cells from a spatial perspective, and pave the way for novel adjuvant treatments for tuberculosis.
Topics & Concepts
Immune systemMycobacterium tuberculosisTuberculosisLungTranscriptomeBiologyGreater omentumGranulomaMicrobiologyImmunologyPathologyMedicineGeneAnatomyGeneticsGene expressionInternal medicineTuberculosis Research and EpidemiologyDiagnosis and treatment of tuberculosisMycobacterium research and diagnosis