Pancreatic ductal deletion of S100A9 alleviates acute pancreatitis by targeting VNN1-mediated ROS release to inhibit NLRP3 activation
Hong Xiang, Fangyue Guo, Xufeng Tao, Qi Zhou, Shilin Xia, Dawei Deng, Lunxu Li, Dong Shang
Abstract
Our study showed the important regulatory effect of S100A9 on pancreatic duct injury during AP and revealed that inhibition of the S100A9-VNN1 interaction may be a key therapeutic target for this disease.
Topics & Concepts
Acute pancreatitisPancreatic ductal adenocarcinomaPancreatitisCancer researchChemistryMedicineReactive oxygen speciesPathologyCell biologyInternal medicinePancreatic cancerBiologyBiochemistryCancerNeonatal Respiratory Health ResearchPancreatitis Pathology and TreatmentBlood Coagulation and Thrombosis Mechanisms