Catalytic Application of Functionalized Bimetallic–Organic Frameworks with Phosphorous Acid Tags in the Synthesis of Pyrazolo[4,3-<i>e</i>]pyridines
Milad Mohammadi Rasooll, Hassan Sepehrmansourie, Mahmoud Zarei, Mohammad Ali Zolfigol, Mojtaba Hosseinifard, Yanlong Gu
Abstract
High Resolution Image Download MS PowerPoint Slide Combining two different metals for the synthesis of a metal–organic framework (MOF) is a smart strategy for the architecture of new porous materials. Herein, a bimetal–organic framework (bimetal–MOFs) based on Fe and Co metals was synthesized. Then, phosphorous acid tags were decorated on bimetal–MOFs via a postmodification method as a new porous acidic functionalized catalyst. This catalyst was used for the synthesis of pyrazolo[4,3- e ]pyridine derivatives as suitable drug candidates. The present study provides new insights into the architecture of novel porous heterogeneous catalysts based on a bimetal–organic framework (bimetal–MOFs). The type of final structures of catalyst and pyrazolo[4,3- e ]pyridine derivatives were determined using different techniques such as fourier transform infrared (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), SEM-elemental mapping, N 2 adsorption–desorption isotherm, Barrett–Joyner–Halenda (BJH), thermogravimetry/differential thermal analysis (TG/DTA), 1 H NMR, and 13 C NMR.