Sex-Related Differences in Left Ventricular Geometry Patterns in Patients With Arterial Hypertension
Grazia Canciello, Raffaele Piccolo, Raffaele Izzo, Eduardo Bossone, Daniela Pacella, Maria Lembo, Maria Virginia Manzi, Costantino Mancusi, Fiorenzo Simonetti, Felice Borrelli, Giuseppe Giugliano, Giovanni Esposito, Maria Angela Losi
Abstract
Background: Sex-specific differences in left ventricular (LV) geometry might help in developing tailored strategies for hypertension management. Objectives: The purpose of the study was to evaluate sex-related differences in LV geometry at baseline and over time in hypertension. Methods: in males and >95 g/m2 in females, identified LV hypertrophy (LVH). Relative wall thickness ≥0.43 defined LV concentric geometry. LVH in presence of concentric geometry was defined as concentric LVH, whereas relative wall thickness <0.43 was categorized as eccentric. Concentric geometry, or LVH, identified LV remodeling. Results: < 0.001). Conclusions: We found sex-related differences in LV geometry among hypertensives. Females have higher risk of LV remodeling at baseline compared with males, with differences persisting at long-term follow-up.