Multidrug resistance: The clinical dilemma of refractory Helicobacter pylori infection
Chia‐Jung Kuo, Cheng‐Han Lee, Ming‐Ling Chang, Cheng‐Yu Lin, Wey‐Ran Lin, Ming‐Yao Su, Cheng‐Hsun Chiu, Cheng‐Hsun Chiu, Chi‐Nan Tseng, Yu‐Shan Wu, Cheng‐Tang Chiu, Cheng‐Tang Chiu, Chih‐Ho Lai
Abstract
This study investigated the antimicrobial resistance of isolates from patients with refractory Helicobacter pylori. The resistance rate was 34.1% for amoxicillin, 92.7% for clarithromycin, 65.9% for metronidazole, 85.4% for levofloxacin, and 29.3% for rifabutin. Dual resistance to both clarithromycin and levofloxacin was found in 73.2%. The antimicrobial resistance rate of refractory H. pylori was extremely high, which had become a major consideration in therapeutic challenge.
Topics & Concepts
RifabutinLevofloxacinClarithromycinAmoxicillinHelicobacter pyloriRefractory (planetary science)MetronidazoleMedicineAntibiotic resistanceMultiple drug resistanceAntimicrobialAntibioticsDrug resistanceMicrobiologyGastroenterologyBiologyAstrobiologyHelicobacter pylori-related gastroenterology studiesVeterinary medicine and infectious diseasesClostridium difficile and Clostridium perfringens research