Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition
Yufei Han, Ye Tian, Ruxin Wang, Siyu Fu, Jia Jiang, Jiawen Dong, Mingze Qin, Yunlei Hou, Yanfang Zhao
Topics & Concepts
ChemistryPI3K/AKT/mTOR pathwayPropidium iodidePyrimidineHydrazideApoptosisCell growthStereochemistryBiochemistryProgrammed cell deathOrganic chemistryPI3K/AKT/mTOR signaling in cancerSynthesis and biological activityCancer Mechanisms and Therapy