Candida Endocarditis in Patients with Candidemia: A Single-Center Experience of 14 Cases
Florian Hitzenbichler, Tobias Joha, Michaela Simon, Jirka Grosse, Karin Menhart, D. Hellwig, Daniele Camboni, Sabine Sag, Can Martin Sag, Frank Hanses, Bernd Salzberger, Arno Mohr
Abstract
Abstract A retrospective, single-center analysis of 14 cases of Candida endocarditis (from 355 candidemia cases during the years 2012–2019) revealed a high in-hospital mortality (57.1%), a high proportion of healthcare-associated infections (13/14) and a high treatment preference for echinocandins. Transthoracic echocardiography and 18 F-FDG PET/CT had a sensitivity of 54.5% and 57.1%, respectively. Patients were older than previously described and most patients with Candida endocarditis had persistent candidemia for ≥ 3 days despite antifungal therapy.
Topics & Concepts
EndocarditisEchinocandinsMedical microbiologyMedicineSingle CenterAntifungalInfective endocarditisRetrospective cohort studyInternal medicineVoriconazoleCaspofunginDermatologyImmunologyAntifungal resistance and susceptibilityInfective Endocarditis Diagnosis and ManagementAntimicrobial Resistance in Staphylococcus