Efficient analysis of pharmaceutical drug substances and products using a solid-state NMR CryoProbe
Yong Du, Jochem Struppe, Barbara Perrone, Alia Hassan, Anna Codina, Yongchao Su
Abstract
N correlation experiments, which are otherwise time-prohibitive using regular MAS probes, for resonance assignment and structural elucidation. These polarization transfer and correlation experiments reveal drug-drug and drug-polymer interactions in amorphous POSA and its amorphous solid dispersion formulation. Our results demonstrated that the CPMAS CryoProbe™ can be widely applied for routine pharmaceutical analysis and advanced structural investigations with significantly enhanced efficiency and throughput.
Topics & Concepts
Solid-state nuclear magnetic resonanceAmorphous solidDrugSolid-stateChemistryMaterials scienceNuclear magnetic resonanceAnalytical Chemistry (journal)ChromatographyCrystallographyPhysical chemistryPharmacologyMedicinePhysicsAdvanced NMR Techniques and ApplicationsMuon and positron interactions and applicationsSolid-state spectroscopy and crystallography