Orchestrated metal-coordinated carrier-free celastrol hydrogel intensifies T cell activation and regulates response to immune checkpoint blockade for synergistic chemo-immunotherapy
Linying Wu, Wenmin Pi, Huang Xuemei, Luping Yang, Xiang Zhang, Jihui Lu, Shuchang Yao, Xia Li, Xinru Tan, Zhixia Wang, Penglong Wang, Penglong Wang
Topics & Concepts
ImmunotherapyTumor microenvironmentMaterials scienceImmune checkpointSelf-healing hydrogelsBlockadeCancer researchCancer immunotherapyCancer therapyImmune systemNanotechnologyCell biologyChemistryBiochemistryCancerReceptorMedicineImmunologyBiologyTumor cellsPolymer chemistryInternal medicineNanoparticle-Based Drug DeliveryImmunotherapy and Immune ResponsesRNA Interference and Gene Delivery