Low protein expression enhances phenotypic evolvability by intensifying selection on folding stability
Shraddha Karve, Pouria Dasmeh, Jia Zheng, Andreas Wagner
Topics & Concepts
EvolvabilityPhenotypeGreen fluorescent proteinProtein foldingBiologyProtein expressionProtein stabilitySelection (genetic algorithm)Protein engineeringComputational biologyEvolutionary biologyGeneticsCell biologyGeneBiochemistryComputer scienceEnzymeArtificial intelligenceEvolution and Genetic DynamicsProtein Structure and DynamicsMicrobial Metabolic Engineering and Bioproduction