Direct C–H fluorination/heteroarylation of oxindoles with quinoxalin-2(1<i>H</i>)-ones using Selectfluor
Hui Qin, Guoliang Wei, Wen-Geng Xie, Xiaohong Mao, Fu-Wei Wang, Meihua Bao, Xiaowei Zheng, Yiwen Zhang, Ping Huang
Abstract
Herein, we present an efficient and feasible strategy for direct C–H fluorination and heteroarylation of oxindoles on the C-3 position having a C(sp 3 )–H bond with quinoxalin-2(1 H )-ones based on a radical coupling reaction via Selectfluor.
Topics & Concepts
SelectfluorChemistryPharmacologyMedicinal chemistryMedicineOrganic chemistryCatalysisFluorine in Organic ChemistrySynthesis and Biological EvaluationCatalytic C–H Functionalization Methods