Immunological mechanism of Sr/Cu ion synergistically promote implant osseointegration
Lei Wang, Xin Yang, Xin Yang, Weiwei Zheng, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Chao Wang, Haoran Lin, Pingbo Chen, Tingjun Ye, Xing Yang, Xing Yang, Qiang Wang
Abstract
Controlled immune response, enhanced osteogenesis, and antibacterial effect are essential for successful implanted biomaterials in the long-term. However, the previous research only considers one of the above-mentioned materials’ properties, and the potential synergetic effects are still unknown. Inspired by the mussel adhesion-mediated ions-coordinated strategy, a multifunctional coating integrated with bioactive Sr2+ and antibacterial Cu2+ was fabricated the multifunctional PEEK implants (PEEK-PDA-Sr/Cu). Compared to the uncoating PEEK, the PEEK implants with a multifunctional coating can regulate the M1 subtypes of macrophages to M2 subtypes due to the presence of Sr2+, which further promote the osteogenic differentiation of BMSCs. Even under the bacterial infection environment, the PEEK implants with a multifunctional coating can still enhance the osseointegration of bone implants due to the antibacterial properties of Cu2+. Taken together, PEEK implants with a multifunctional coating can provide an osteogenic immune microenvironment with enhanced osteogenesis and antibacterial property, which is essential for successful implantation in the long-term.