A novel biocompatible, simvastatin-loaded, bone-targeting lipid nanocarrier for treating osteoporosis more effectively
Shan Tao, Shaoqing Chen, Wentao Zhou, Fangying Yu, Lu Bao, Guoxi Qiu, Qing Qiao, Fuqiang Hu, Jianwei Wang, Hong Yuan
Abstract
A scheme of the preparation of SIM/ASP<sub>6</sub>-LNPs and a mechanism which indicated that SIM/ASP<sub>6</sub>-LNPs could improve the efficacy of SIM on the recovery of osteoporosis under the action of bone-targeting moieties ASP<sub>6</sub>.
Topics & Concepts
OsteoporosisOsteoblastChemistrySimvastatinNanocarriersBisphosphonateIn vivoDrugBone mineralPharmacologyIn vitroMedicineInternal medicineBiochemistryBiologyBiotechnologyLipid Membrane Structure and BehaviorNanoparticle-Based Drug DeliveryBone and Joint Diseases