Targeting heat shock protein 47 alleviated doxorubicin-induced cardiotoxicity and remodeling in mice through suppression of the NLRP3 inflammasome
Wenke Shi, Jiaojiao Chen, Nan Zhao, Yun Xing, Shiqiang Liu, Mengya Chen, Wenxi Fang, Tong Zhang, Lanlan Li, Heng Zhang, Min Zhang, Xiaofeng Zeng, Si Chen, Shasha Wang, Saiyang Xie, Wei Deng
Topics & Concepts
DoxorubicinCardiotoxicityGene knockdownAnthracyclineIn vivoMedicineCancer researchHeart failureTXNIPHeat shock proteinPharmacologyCancerChemotherapyInternal medicineBiologyApoptosisOxidative stressBiochemistryBiotechnologyGeneBreast cancerThioredoxinChemotherapy-induced cardiotoxicity and mitigationHeat shock proteins researchInflammasome and immune disorders