A multifunctional quercetin/polycaprolactone electrospun fibrous membrane for periodontal bone regeneration
Y. N. Hu, Zeyu Fu, Shiyuan Yang, Yuning Zhou, Huimin Zhu, Yan Zhu, Jia Zhou, Kaili Lin, Yuanjin Xu
Abstract
• The Qtn/PCL electrospun membranes possessed reinforced mechanical property, sustained release ability and tunable degradation profile. • The Qtn/PCL electrospun membranes exhibited good cytocompatibility towards both hPDLSCs and NIH3T3 fibroblasts. • The Qtn/PCL electrospun membranes markedly enhanced the osteogenic and angiogenic differentiation as well as migration of hPDLSCs in vitro. • The Qtn/PCL electrospun membranes prevented HGFs from growing into periodontal bone defect sites, thus exerted a barrier function. • The Qtn/PCL membranes could promote periodontal bone regeneration in rat periodontal bone defects in vivo .
Topics & Concepts
PolycaprolactoneRegeneration (biology)MembraneElectrospinningNanofiberDentistryBiomedical engineeringMaterials scienceChemistryComposite materialMedicineCell biologyPolymerBiochemistryBiologyElectrospun Nanofibers in Biomedical ApplicationsPeriodontal Regeneration and TreatmentsOral microbiology and periodontitis research