Intracellular Staphylococcus aureus Perturbs the Host Cell Ca <sup>2+</sup> Homeostasis To Promote Cell Death
Kathrin Stelzner, Ann-Cathrin Winkler, Chunguang Liang, Aziza Boyny, Carsten P. Ade, Thomas Dandekar, Martin Fraunholz, Thomas Rudel
Abstract
Despite being regarded as an extracellular bacterium, the pathogen Staphylococcus aureus can invade and survive within human cells. The intracellular niche is considered a hideout from the host immune system and antibiotic treatment and allows bacterial proliferation.
Topics & Concepts
IntracellularStaphylococcus aureusHomeostasisCell biologyCellMicrobiologyChemistryHost (biology)Programmed cell deathBacteriaBiologyBiochemistryApoptosisGeneticsAntimicrobial Resistance in StaphylococcusMicrobial Metabolism and ApplicationsBacterial biofilms and quorum sensing