Wnt/β-Catenin Signaling Pathway in the Development and Progression of Colorectal Cancer
Kuang He, Wen-Juan Gan
Abstract
The Wnt/β-catenin signaling pathway is a growth control pathway involved in various biological processes as well as the development and progression of cancer. Colorectal cancer (CRC) is one of the most common malignancies in the world. The hyperactivation of Wnt signaling is observed in almost all CRC and plays a crucial role in cancer-related processes such as cancer stem cell (CSC) propagation, angiogenesis, epithelial-mesenchymal transition (EMT), chemoresistance, and metastasis. This review will discuss how the Wnt/β-catenin signaling pathway is involved in the carcinogenesis and progression of CRC and related therapeutic approaches.
Topics & Concepts
Wnt signaling pathwayColorectal cancerCancer researchCarcinogenesisMetastasisEpithelial–mesenchymal transitionCateninCancer stem cellAngiogenesisSignal transductionCancerTumor progressionMedicineBiologyInternal medicineCell biologyWnt/β-catenin signaling in development and cancerCancer-related gene regulationHedgehog Signaling Pathway Studies