B<sub>2</sub>cat<sub>2</sub>‐Mediated Reduction of Sulfoxides to Sulfides
Fumiya Takahashi, Keisuke Nogi, Hideki Yorimitsu
Abstract
An efficient and operationally simple method for the reduction of sulfoxides to sulfides has been developed using bis(catecholato)diboron (B 2 cat 2 ) as a reducing agent. The present method accommodates various functional groups which are generally prone to reduction: halides, alkynes, carbonyls, nitriles, and heterocycles are totally intact, and only sulfoxide moieties undergo reduction chemoselectively. Moreover, the remaining diboron and the resulting boron‐containing wastes are readily removable, the practicality of this protocol being thus demonstrated.
Topics & Concepts
ChemistryHalideReduction (mathematics)BoronSulfoxideCombinatorial chemistryReducing agentOrganic chemistryMedicinal chemistryGeometryMathematicsSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsCatalytic C–H Functionalization Methods