A Catellani and <i>retro</i>-Diels–Alder strategy to access 1-amino phenanthrenes <i>via ortho</i>- and interannular C–H activation of 2-iodobiphenyls
Mingjie Sun, Xinyang Chen, Zichao Feng, Guobo Deng, Yuan Yang, Yun Liang
Abstract
A palladium-catalyzed three-component domino reaction for the construction of 1-amino phenanthrene derivatives by ortho - and interannular C–H activation of 2-iodobiphenyls has been developed.
Topics & Concepts
PhenanthrenesChemistryPhenanthreneDominoDiels–Alder reactionCatalysisPalladiumMedicinal chemistryComponent (thermodynamics)StereochemistryOrganic chemistryCombinatorial chemistryThermodynamicsPhysicsCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsCatalytic Cross-Coupling Reactions