A Straightforward Approach to Fluorinated Pyrimido[1,2-<i>b</i>]indazole Derivatives via Metal/Additive-Free Annulation with Enaminones, 3-Aminoindazoles, and Selectfluor
Zhaoliang Xu, Xiao Geng, Yiwen Cai, Lei Wang
Abstract
A novel and efficient three-component reaction with two C–N bonds and one C–F bond formation has been reported, which provides a straightforward route to a variety of fluorinated pyrimido[1,2-b]indazole derivatives. This transformation has the advantage of excellent functional group compatibility, including aliphatic and aromatic substituents enaminones. Moreover, metal and additives are not necessary for this reaction, which is of great significance for the synthesis and application of fluorinated heterocycles.
Topics & Concepts
IndazoleSelectfluorChemistryAnnulationCombinatorial chemistryMetalReaction conditionsFunctional groupOrganic chemistryCatalysisPolymerFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms