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Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity

Mohamed G. Thabit, Amany Mostafa, Khalid B. Selim, Magda A.‐A. El‐Sayed, Magda N.A. Nasr

2020Bioorganic Chemistry21 citationsDOI

Topics & Concepts

ChemistryIC50SorafenibStereochemistryCell cycle checkpointCell cultureEnzymeCell cycleApoptosisLead compoundInhibitory postsynaptic potentialIn vitroBiochemistryCancer researchInternal medicineBiologyGeneticsMedicineHepatocellular carcinomaMelanoma and MAPK PathwaysSynthesis and biological activityCancer Mechanisms and Therapy
Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity | Litcius