Adjuvant-free peptide vaccine targeting Clec9a on dendritic cells can induce robust antitumor immune response through Syk/IL-21 axis
Shanshan Gou, Shuai Wang, Wenwen Liu, Guanyu Chen, Dongyang Zhang, Jiangfeng Du, Zhongyi Yan, Hongfei Wang, Wenjie Zhai, Xinghua Sui, Yahong Wu, Yuanming Qi, Yanfeng Gao
Abstract
CBP-12 could serve as an adjuvant-free peptide vaccine carrier for cancer immunotherapy.
Topics & Concepts
AdjuvantAntigenCross-presentationImmune systemCytotoxic T cellDendritic cellImmunologyAntigen presentationCD8EpitopeCancer immunotherapyCancer researchCancer vaccineT cellImmunotherapyChemistryBiologyBiochemistryIn vitroImmunotherapy and Immune ResponsesCancer Immunotherapy and BiomarkersRNA Interference and Gene Delivery