Synthesis and characterization of new potent TLR7 antagonists based on analysis of the binding mode using biomolecular simulations
Sourav Pal, Barnali Paul, Purbita Bandopadhyay, Nagothy Preethy, Dipika Sarkar, Oindrila Rahaman, Sunny Goon, Swarnali Roy, Dipyaman Ganguly, Arindam Talukdar
Topics & Concepts
TLR7ChemistryRational designDocking (animal)Small moleculeEndosomeComputational biologyMolecular modelLigand (biochemistry)StereochemistryReceptorBiochemistryToll-like receptorBiologyGeneticsInnate immune systemMedicineNursingImmune Response and InflammationImmunotherapy and Immune ResponsesT-cell and B-cell Immunology