MiR‐9‐5p Inhibits the MMP<sup>+</sup>‐Induced Neuron Apoptosis through Regulating SCRIB/<i>β</i>‐Catenin Signaling in Parkinson’s Disease
Zhenyong Xiao, Zhenxing Yan, Xiang Sun, Zhiyuan Zhu, Baoyan Wang, Mengqi Gao, Fengfei Lu, Jian Liu, Zhitao Zong, Hongbo Zhang, Yanwu Guo
Abstract
The pathogenesis of Parkinson’s disease remains unclear that there is no cure for Parkinson’s disease yet. The abnormal expressions of certain miRNA are closely related to the occurrence and progression of Parkinson’s disease. Here, we demonstrate that miR‐9‐5p inhibits the dopaminergic neuron apoptosis via the regulation of β ‐catenin signaling which directly targets SCRIB, a tumor suppressor gene. Besides, miR‐9‐5p improved the motor function of mice with Parkinson’s disease. The results of this study suggest that miR‐9‐5p might be a potential therapeutic target against Parkinson’s disease.
Topics & Concepts
Parkinson's diseaseDiseasePathogenesisNeuroscienceDopaminergicBiologyApoptosisCateninSignal transductionCancer researchMedicineDopamineCell biologyImmunologyWnt signaling pathwayInternal medicineGeneticsNerve injury and regenerationSignaling Pathways in DiseaseNuclear Receptors and Signaling