Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combining Bdnf-e6 deficiency and developmental stress
Yanhui Chen, Shangjin Li, Tianyi Zhang, Feng Yang, Bai Lu
Abstract
mice were rescued by treatment with the corticosterone antagonist RU-486, or the BDNF mimetic TrkB agonistic antibody. Thus, we have identified a pair of genetic and environmental factors contributing to schizophrenia pathogenesis and providing a potential strategy for therapeutic interventions for schizophrenia.
Topics & Concepts
CorticosteroneTropomyosin receptor kinase BPrepulse inhibitionSchizophrenia (object-oriented programming)EndocrinologyAntagonistInternal medicineSocial defeatAgonistPathogenesisPsychologyNeuroscienceMedicineNeurotrophic factorsReceptorPsychiatryHormoneStress Responses and CortisolTryptophan and brain disordersNeuroendocrine regulation and behavior