Base Excision Repair in the Immune System: Small DNA Lesions With Big Consequences
Maria Stratigopoulou, Tijmen van Dam, Jeroen E. J. Guikema
Abstract
loci has been linked to mutations observed in B-cell tumors and DNA breaks and chromosomal translocations in activated B cells. Next to its role in preventing cancer, BER has also been implicated in immune tolerance. Several defects in BER components have been associated with autoimmune diseases, and animal models have shown that BER defects can cause autoimmunity in a B-cell intrinsic and extrinsic fashion. In this review we discuss the contribution of BER to genomic integrity in the context of immune receptor diversification, cancer and autoimmune diseases.
Topics & Concepts
Somatic hypermutationBase excision repairDNA damageDNA repairBiologyCytidine deaminaseDNADNA glycosylaseDNA mismatch repairV(D)J recombinationActivation-induced (cytidine) deaminaseImmunoglobulin class switchingMolecular biologyNucleotide excision repairGeneticsB cellAntibodyCancer researchGeneRecombinationDNA Repair MechanismsPolyomavirus and related diseasesImmunodeficiency and Autoimmune Disorders