Structural elucidation and hypoglycemic effect of an inulin-type fructan extracted from <i>Stevia rebaudiana</i> roots
Zhiyan Tang, Taili Shao, Lan Gao, Pingchuan Yuan, Zhengrui Ren, Lei Tian, Wei Liu, Chunyan Liu, Xiuxian Xu, Xuan Zhou, Jun Han, Guodong Wang
Abstract
assays revealed that SRRP significantly reduced fasting blood glucose levels, improved insulin resistance, decreased oxidative stress, and regulated lipid metabolism in T2DM mouse models. In addition, SRRP altered the diversity of the gut microbiota and its metabolites in T2DM mice; it increased probiotic bacteria and the concentration of short-chain fatty acids and decreased harmful bacteria. The findings demonstrate the potential of SRRP in the treatment of T2DM.
Topics & Concepts
Stevia rebaudianaFructanSteviaInulinChemistrySteviosideTraditional medicineBiochemistryFood scienceMedicineFructoseAlternative medicinePathologyBiochemical Analysis and Sensing TechniquesMicrobial Metabolites in Food BiotechnologyPhytochemicals and Antioxidant Activities