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Identification and Characterization of a Novel Major Facilitator Superfamily Efflux Pump, SA09310, Mediating Tetracycline Resistance in Staphylococcus aureus

Daiyu Li, Yan Ge, Ning Wang, Yun Shi, Gang Guo, Quanming Zou, Qiang Liu

2023Antimicrobial Agents and Chemotherapy17 citationsDOIOpen Access PDF

Abstract

-dependent activity of the SA09310 efflux pump. The conservation of SA09310 homologs in Staphylococcus indicated the universal function of these SA09310-like protein clusters. In conclusion, the function-unknown protein SA09310 has been identified and characterized as a tetracycline efflux pump mediating tetracycline resistance in S. aureus.

Topics & Concepts

Major facilitator superfamilyEffluxStaphylococcus aureusFacilitatorTetracyclineMicrobiologySUPERFAMILYIdentification (biology)Antibiotic resistanceBiologyAntibioticsBacteriaGeneticsTransporterPsychologyGeneBotanySocial psychologyAntimicrobial Resistance in StaphylococcusAntibiotic Resistance in BacteriaMycobacterium research and diagnosis