Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β Fibrils
Dan E. Adolfsson, Mohit Tyagi, Pardeep Singh, Adrian Deuschmann, Jörgen Ådén, Anna L. Gharibyan, Sanduni Wasana Jayaweera, Anders E. G. Lindgren, Anders Olofsson, Fredrik Almqvist
Abstract
. Analogues substituted with a nitro group bind to mature amyloid fibrils, and the activity moreover depends on the positioning of this functional group.
Topics & Concepts
Intramolecular forceChemistryPeptidomimeticAmyloid fibrilNitroFibrilIn vitroAmyloid βAlkylationCombinatorial chemistryAmyloid (mycology)StereochemistryFolding (DSP implementation)CatalysisBiochemistryPeptideOrganic chemistryEngineeringElectrical engineeringInorganic chemistryAlkylDiseasePathologyMedicineChemical Synthesis and AnalysisSynthesis and Reactivity of HeterocyclesMulticomponent Synthesis of Heterocycles