Quality by Design Strategy for Simultaneous HPLC Determination of Bromhexine HCl and Its Metabolite Ambroxol HCl in Dosage Forms and Plasma
Heba M. El-Sayed, Hisham Hashem
Topics & Concepts
ChemistryChromatographyAmbroxolFractional factorial designCentral composite designResponse surface methodologyFactorial experimentHigh-performance liquid chromatographyMetaboliteDetection limitChromatographic separationBiochemistryMedicineStatisticsMathematicsAnesthesiaAnalytical Methods in PharmaceuticalsAnalytical Chemistry and ChromatographyAntibiotics Pharmacokinetics and Efficacy