Allosteric inhibition of SARS-CoV-2 3CL protease by colloidal bismuth subcitrate
Xuan Tao, Lu Zhang, Liubing Du, Ruyan Liao, Huiling Cai, Kai Lǚ, Zhennan Zhao, Yanxuan Xie, Pei‐Hui Wang, Ji-An Pan, Yuebin Zhang, Guohui Li, Jun Dai, Zong‐Wan Mao, Wei Xia
Abstract
. Rather than targeting the cysteine residue at the catalytic site, CBS binds to an allosteric site and results in dissociation of the 3CLpro dimer and proteolytic dysfunction. Our work provides direct evidence that CBS is an allosteric inhibitor of SARS-CoV-2 3CLpro.
Topics & Concepts
Allosteric regulationChemistryProteaseCysteineCysteine proteaseProteasesVirologyEnzymeBiochemistryBiologySARS-CoV-2 and COVID-19 ResearchViral Infections and Immunology ResearchCOVID-19 Clinical Research Studies