Construction of axially chiral styrene-type allylamines<i>via</i>chiral phosphoric acid-catalyzed asymmetric reductive amination
You‐Dong Shao, Jin-Shuo Feng, Dandan Han, Kang-Hui Pan, Ling Zhang, Yifan Wang, Zhonghui Ma, Peiru Wang, Mingjing Yin, Dao‐Juan Cheng
Abstract
The first enantioselective synthesis of axially chiral styrene-type allylamines through chiral phosphoric acid mediated atroposelective reductive amination of 1-enal substituted 2-naphthols is achieved.
Topics & Concepts
ChemistryReductive aminationStyrenePhosphoric acidCatalysisAminationOrganic chemistryAxial symmetryPolymer chemistryCopolymerPhysicsQuantum mechanicsPolymerAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityAsymmetric Synthesis and Catalysis