Engineering Endogenous Tumor‐Associated Macrophage‐Targeted Biomimetic Nano‐RBC to Reprogram Tumor Immunosuppressive Microenvironment for Enhanced Chemo‐Immunotherapy (Adv. Mater. 39/2021)
Yupeng Wang, Jie Yu, Zhijian Luo, Qiankun Shi, Guanglong Liu, Fan Wu, Zhizhang Wang, Yubin Huang, Dongfang Zhou
Abstract
Cancer Chemo-Immunotherapy In article number 2103497, Yubin Huang, Dongfang Zhou, and co-workers demonstrate an engineered endogenous tumor-associated macrophages (TAMs)-targeting biomimetic nano-red-blood-cell (RBC) system to deliver chemotherapeutic doxorubicin and oxygen for enhanced cancer chemo-immunotherapy. TAMs-targeting depletion and hypoxia alleviation synergistically reprogram the tumor immunosuppressive microenvironment. The ensuing TAMs-targeted chemo-immunotherapeutic effects markedly inhibit tumor metastasis and recurrence.
Topics & Concepts
Tumor microenvironmentImmunotherapyCancer researchCancer immunotherapyTumor-associated macrophageMetastasisDoxorubicinCancerMaterials scienceImmune systemMedicineImmunologyTumor cellsChemotherapyInternal medicineNanoplatforms for cancer theranosticsImmune cells in cancerExtracellular vesicles in disease