Inhibition of glycosphingolipid biosynthesis reverts multidrug resistance by differentially modulating ABC transporters in chronic myeloid leukemias
Eduardo J. Salustiano, Kelli Monteiro da Costa, Leonardo Freire‐de‐Lima, Lúcia Mendonça‐Previato, José O. Previato
Abstract
-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.
Topics & Concepts
CeramideATP-binding cassette transporterSphingolipidBiologyGlycosphingolipidEffluxMultiple drug resistanceCancer cellCeramide synthaseBiosynthesisBiochemistryCell biologyCancer researchTransporterDrug resistanceCancerApoptosisEnzymeGeneGeneticsDrug Transport and Resistance MechanismsSphingolipid Metabolism and SignalingImmune Cell Function and Interaction